Endotoxin Impairs Agonist-induced Calcium Mobilization in Rat Mesangial Cells
نویسندگان
چکیده
منابع مشابه
Endotoxin impairs agonist-induced calcium mobilization in rat mesangial cells.
We hypothesized that endotoxin would impair agonist-induced calcium (Ca2+) mobilization in rat mesangial cells, owing to the induction of nitric oxide synthase (NOS) and augmented nitric oxide (NO) synthesis. We measured basal and bradykinin-induced peak free cytosolic Ca2+ concentrations through microspectrofluorimetry with fura-2 in confluent mesangial cells, and assayed conditioned medium fo...
متن کاملLead exposure impairs the NMDA agonist-induced NOS expression in pyramidal hippocampal cells
Chronic exposure to lead (Pb) affects neural functions in central nervous system (CNS) particularly the learning and memory. On the other hand, alteration of calcium level in the CNS results in activation of NOS. It has been shown that lead enters the neurons through calcium channels and displaces Ca2+ from calcium binding proteins such as calmodulin and troponin C thereby affecting calcium-med...
متن کاملLead exposure impairs the NMDA agonist-induced NOS expression in pyramidal hippocampal cells
Chronic exposure to lead (Pb) affects neural functions in central nervous system (CNS) particularly the learning and memory. On the other hand, alteration of calcium level in the CNS results in activation of NOS. It has been shown that lead enters the neurons through calcium channels and displaces Ca2+ from calcium binding proteins such as calmodulin and troponin C thereby affecting calcium-med...
متن کاملlead exposure impairs the nmda agonist-induced nos expression in pyramidal hippocampal cells
chronic exposure to lead (pb) affects neural functions in central nervous system (cns) particularly the learning and memory. on the other hand, alteration of calcium level in the cns results in activation of nos. it has been shown that lead enters the neurons through calcium channels and displaces ca2+ from calcium binding proteins such as calmodulin and troponin c thereby affecting calcium-med...
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BACKGROUND In many cells, depletion of intracellular calcium (Ca2+) reservoirs triggers Ca2+ entry through store-operated Ca2+ channels in the plasma membrane. However, the mechanisms of agonist-induced calcium entry (ACE) in keratinocytes are not fully understood. OBJECTIVES This study was designed to determine if pharmacological inhibition of calcium-independent phospholipase A (iPLA(2)) im...
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ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 1997
ISSN: 1073-449X,1535-4970
DOI: 10.1164/ajrccm.156.6.9701067